Hippocampal Epilepsy and Memory

Mesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis is the most common, focal, drug-resistant epilepsy syndrome. Memory dysfunction is the primary cognitive complaint in patients with MTLE, impacting almost all patients. Uncontrolled hippocampal seizures that disrupt hippocampal function impact memory function. Surgical destruction of the hippocampus results in cure from seizures in most patients, but further worsens memory post-operatively in up to half of patients.

We have several ongoing projects in collaboration with the Manoach Lab, the Han Lab, the Kramer Lab, and the Eden Lab to understand the cellular networks underlying neural oscillations that support memory, how these oscillations are impacted by epilepsy, and to test interventions to improve memory in patients with epilepsy.

If you would like to support these projects, click here.

To return to the project page, click here.