Publications

2022

Spencer ER, Chinappen D, Emerton BC, Morgan AK, Hämäläinen MS, Manoach DS, Eden UT, Kramer MA, Chu CJ. Source EEG reveals that Rolandic epilepsy is a regional epileptic encephalopathy. Neuroimage Clin. 2022;33:102956. PMID: 35151039; PMCID: PMC8844714. [link] [pdf]

Kwon H, Walsh KG, Berja ED, Manoach DS, Eden UT, Kramer MA, Chu CJ. Normative sleep spindle database and findings from 772 healthy children from birth through 18 years. Biorxiv. [pdf]

Kwon H, Chinappen DM, Huang JF, Berja ED, Walsh KG, Wen S, Kramer MA, Chu CJ. Transient, developmental functional and structural connectivity abnormalities in the thalamocortical motor network in Rolandic epilepsy. Neuroimage Clin. 2022 (in press). [pdf]

Massey SL, Glass HC, Shellhaas RA, Bonifacio S, Chang T, Chu C, Cilio MR, Lemmon ME, McCulloch CE, Soul JS, Thomas C, Wusthoff CJ, Xiao R, Abend NS. Characteristics of Neonates with Cardiopulmonary Disease Who Experience Seizures: A Multicenter Study. J Pediatr. 2022 Mar;242:63-73. PMID: 34728234; PMCID: PMC8882137. [link] [pdf]

Abend N, Adams E, Al Balushi A, Alburaki W, Appendino J, Barbosa VS, Birca A, Bonifacio S, Branagan A, Chang T, Chowdhury R, Christou H, Chu C, Cilio MR, Comani S, Corsi-Cabrera M, Croce P, Cubero-Rego L, Dawoud F, de Vries L, Dehaes M, Devane D, Duncan A, El Ters N, El-Dib M, Elshibiny H, Esser M, Fairchild K, Finucane E, Franceschini MA, Gallagher A, Ghosh A, Glass H, Venkata SKRG, Baillet TH, Herzberg E, Hildrey E, Hurley T, Inder T, Jacobs E, Jefferies K, Jermendy A, Khazaei M, Kilmartin K, King G, Lauronen L, Lee S, Leijser L, Lind J, Llaguno NS, Machie M, Magalhães M, Mahdi Z, Maluomi J, Marandyuk B, Massey S, McCulloch C, Metsäranta M, Mikkonen K, Mohammad K, Molloy E, Momin S, Munster C, Murthy P, Netto A, Nevalainen P, Nguyen J, Nieves M, Nyman J, Oliver N, Peeters C, Pietrobom RFR, Pijpers J, Pinchefksy E, Ping YB, Quirke F, Raeisi K, Ricardo-Garcell J, Robinson J, Rodrigues DP, Rosati J, Scott J, Scringer-Wilkes M, Shellhaas R, Smit L, Soul J, Srivastava A, Steggerda S, Sunwoo J, Szakmar E, Tamburro G, Thomas S, Toiviainen-Salo S, Toma AI, Vanhatalo S, Variane GFT, Vein A, Vesoulis Z, Vilan A, Volpe J, Weeke L, Wintermark P, Wusthoff C, Zappasodi F, Zein H, Zempel J. Proceedings of the 13th International Newborn Brain Conference: Neonatal Neurocritical Care, Seizures, and Continuous EEG monitoring. J Neonatal Perinatal Med. 2022;15(2):467-485. PMID: 35431189. [link] [pdf]

Spencer ER, Shi W, Komorowski RW, Gilbert JP, Ostrowski LM, Bird LM, Thibert R, Bao C, Molloy F, Calhoun M, Koirala S, Jafar-Nejad P, Rigo F, Kramer MA, Chu CJ. Longitudinal EEG model detects antisense oligonucleotide treatment effect and increased UBE3A in Angelman syndrome. Brain Commun. 2022 Apr 26;4(3):fcac106. doi: 10.1093/braincomms/fcac106. PMID: 35611307; PMCID: PMC9123847. [link] [pdf]

Shi W, Zemel D, Sridhar S, Mount RA, Richardson RM, Eden UT, Han X, Kramer MA, Chu CJ. Spike ripples in striatum correlate with seizure risk in two mouse models. Epilepsy Behav Rep. 2022 Feb 8;18:100529. PMID: 35274094; PMCID: PMC8902602. [link] [pdf]

Baumer FM, Mytinger JR, Neville K, Briscoe Abath C, Gutierrez CA, Numis AL, Harini C, He Z, Hussain SA, Berg AT, Chu CJ, Gaillard WD, Loddenkemper T, Pasupuleti A, Samanta D, Singh RK, Singhal NS, Wusthoff CJ, Wirrell EC, Yozawitz E, Knupp KG, Shellhaas RA, Grinspan ZM; Pediatric Epilepsy Research Consortium; National Infantile Spasms Consortium. Inequities in Therapy for Infantile Spasms: A Call to Action. Ann Neurol. 2022 Jul;92(1):32-44. PMID: 35388521. [link] [pdf]

Peyton C, Girvan O, Shellhaas RA, Lemmon ME, Rogers EE, Soul JS, Chang T, Hamlett A, Wusthoff CJ, Chu CJ, Massey SL, Thomas C, Guillet R, Franck LS, Glass HC; Neonatal Seizure Registry. Impact of COVID-19 Pandemic on Developmental Service Delivery in Children With a History of Neonatal Seizures. Pediatr Neurol. 2022 Apr;129:14-18. doi: 10.1016/j.pediatrneurol.2022.01.004. Epub 2022 Jan 21. PMID: 35149302; PMCID: PMC8779856. [link] [pdf]

Herzberg EM, Machie M, Glass HC, Shellhaas RA, Wusthoff CJ, Chang T, Abend NS, Chu CJ, Cilio MR, Bonifacio SL, Massey SL, McCulloch CE, Soul JS; Neonatal Seizure Registry study group. Seizure Severity and Treatment Response in Newborn Infants with Seizures Attributed to Intracranial Hemorrhage. J Pediatr. 2022 Mar;242:121-128.e1. PMID: 34780777. [link] [pdf]

Keene JC, Morgan LA, Abend NS, Bates SV, Bauer Huang SL, Chang T, Chu CJ, Glass HC, Massey SL, Ostrander B, Pardo AC, Press CA, Soul JS, Shellhaas RA, Thomas C, Natarajan N. Treatment of Neonatal Seizures: Comparison of Treatment Pathways From 11 Neonatal Intensive Care Units. Pediatr Neurol. 2022 Mar;128:67-74. doi: 10.1016/j.pediatrneurol.2021.10.004. Epub 2021 Oct 11. PMID: 34750046. [link] [pdf]

2021

Lemmon ME, Glass HC, Shellhaas RA, Barks MC, Bansal S, Annis D, Guerriero JL, Pilon B, Wusthoff CJ, Chang T, Soul JS, Chu CJ, Thomas C, Massey SL, Abend NS, Rau S, Rogers EE, Franck LS; Neonatal Seizure Registry. Family-Centered Care for Children and Families Impacted by Neonatal Seizures: Advice From Parents. Pediatr Neurol. 2021 Nov;124:26-32. PMID: 34509000; PMCID: PMC8523194. [link] [pdf]

Stoyell SM, Wilmskoetter J, Dobrota MA, Chinappen DM, Bonilha L, Mintz M, Brinkmann BH, Herman ST, Peters JM, Vulliemoz S, Seeck M, Hämäläinen MS, Chu CJ. High-Density EEG in Current Clinical Practice and Opportunities for the Future. J Clin Neurophysiol. 2021 Mar 1;38(2):112-123. PMID: 33661787; PMCID: PMC8083969. [link] [pdf]

Nascimento FA, Cochran RL, Chow DZ, Scott JA, Chu CJ. Teaching NeuroImage: Increasing SPECTations for Ictal SPECT in Epilepsy Surgical Evaluation. Neurology. 2021 Aug 10;97(6):e647-e648. PMID: 33903198; PMCID: PMC8424495. [link] [pdf]

Stoyell SM, Baxter BS, McLaren J, Kwon H, Chinappen DM, Ostrowski L, Zhu L, Grieco JA, Kramer MA, Morgan AK, Emerton BC, Manoach DS, Chu CJ. Diazepam induced sleep spindle increase correlates with cognitive recovery in a child with epileptic encephalopathy. BMC Neurol. 2021 Sep 14;21(1):355. PMID: 34521381; PMCID: PMC8438890. [link] [pdf]

Grinspan ZM, Knupp KG, Patel AD, Yozawitz EG, Wusthoff CJ, Wirrell E, Valencia I, Singhal NS, Nordli DR, Mytinger JR, Mitchell W, Keator CG, Loddenkemper T, Hussain SA, Harini C, Gaillard WD, Fernandez IS, Coryell J, Chu CJ, Berg AT, Shellhaas RA. Comparative Effectiveness of Initial Treatment for Infantile Spasms in a Contemporary US Cohort. Neurology. 2021 Jul 15;97(12):e1217–28. PMID: 34266919; PMCID: PMC8480478. [link] [pdf]

Nadalin JK, Eden UT, Han X, Richardson RM, Chu CJ, Kramer MA. Application of a convolutional neural network for fully-automated detection of spike ripples in the scalp electroencephalogram. J Neurosci Methods. 2021 Aug 1;360:109239. PMID: 34090917; PMCID: PMC8324553. [link] [pdf]

Shellhaas RA, Wusthoff CJ, Numis AL, Chu CJ, Massey SL, Abend NS, Soul JS, Chang T, Lemmon ME, Thomas C, McNamara NA, Guillet R, Franck LS, Sturza J, McCulloch CE, Glass HC. Early-life epilepsy after acute symptomatic neonatal seizures: A prospective multicenter study. Epilepsia. 2021 Aug;62(8):1871-1882. PMID: 34212365. [link] [pdf]

Glass HC, Soul JS, Chang T, Wusthoff CJ, Chu CJ, Massey SL, Abend NS, Lemmon M, Thomas C, Numis AL, Guillet R, Sturza J, McNamara NA, Rogers EE, Franck LS, McCulloch CE, Shellhaas RA. Safety of Early Discontinuation of Antiseizure Medication After Acute Symptomatic Neonatal Seizures. JAMA Neurol. 2021 Jul 1;78(7):817-825. PMID: 34028496; PMCID: PMC8145161. [link] [pdf]

Wusthoff CJ, Sundaram V, Abend NS, Massey SL, Lemmon ME, Thomas C, McCulloch CE, Chang T, Soul JS, Chu CJ, Rogers EE, Bonifacio SL, Cilio MR, Glass HC, Shellhaas RA; Neonatal Seizure Registry Group. Seizure Control in Neonates Undergoing Screening vs Confirmatory EEG Monitoring. Neurology. 2021 Aug 10;97(6):e587-e596. PMID: 34078719; PMCID: PMC8424499. [link] [pdf]

McLaren JR, Shi W, Misko AL, Emerton BC, Chu CJ. Hippocampal sharp wave ripples during invasive monitoring: A physiologic finding. Clin Neurophysiol. 2021 May;132(5):1077-1079. PMID: 33743302; PMCID: PMC8511942. [link] [pdf]

Manzano GS, Danish HH, Chu CJ, Kimchi EY. Child Neurology: Intractable Epilepsy and Transient Deficits in a Patient With a History of Herpes Simplex Virus Encephalitis. Neurology. 2021 Apr 6;96(14):679-681. PMID: 33495374; PMCID: PMC8105966. [link] [pdf]

Li Q, Westover MB, Zhang R, Chu CJ. Computational Evidence for a Competitive Thalamocortical Model of Spikes and Spindle Activity in Rolandic Epilepsy. Front Comput Neurosci. 2021 Jun 18;15:680549. PMID: 34220477; PMCID: PMC8249809. [link] [pdf]

Ostrowski LM, Spencer ER, Bird LM, Thibert R, Komorowski RW, Kramer MA, Chu CJ. Delta power robustly predicts cognitive function in Angelman syndrome. Ann Clin Transl Neurol. 2021 Jul;8(7):1433-1445. PMID: 34047077; PMCID: PMC8283185. [link] [pdf]

Zhu X, Shappell H, Kramer MA, Chu CJ, Kolaczyk E. Inferring the type of phase transitions undergone in epileptic seizures using random graph hidden Markov models for percolation in noisy dynamic networks. arXiv: 2021. [pdf]

Crocker B, Ostrowski L, Williams ZM, Dougherty DD, Eskandar EN, Widge AS, Chu CJ, Cash SS, Paulk AC. Local and distant responses to single pulse electrical stimulation reflect different forms of connectivity. Neuroimage. 2021 Aug 15;237:118094. PMID: 33940142. [link] [pdf]

Kramer MA, Stoyell SM, Chinappen D, Ostrowski LM, Spencer ER, Morgan AK, Emerton BC, Jing J, Westover MB, Eden UT, Stickgold R, Manoach DS, Chu CJ. Focal Sleep Spindle Deficits Reveal Focal Thalamocortical Dysfunction and Predict Cognitive Deficits in Sleep Activated Developmental Epilepsy. J Neurosci. 2021 Feb 24;41(8):1816-1829. PMID: 33468567; PMCID: PMC8115887. [link] [pdf]

Yang JC, Paulk AC, Salami P, Lee SH, Ganji M, Soper DJ, Cleary D, Simon M, Maus D, Lee JW, Nahed BV, Jones PS, Cahill DP, Cosgrove GR, Chu CJ, Williams Z, Halgren E, Dayeh S, Cash SS. Microscale dynamics of electrophysiological markers of epilepsy. Clin Neurophysiol. 2021 Nov;132(11):2916-2931. doi: 10.1016/j.clinph.2021.06.024. Epub 2021 Aug 2. PMID: 34419344; PMCID: PMC8545846. [link] [pdf]

Franck LS, Shellhaas RA, Lemmon ME, Sturza J, Barnes M, Brogi T, Hill E, Moline K, Soul JS, Chang T, Wusthoff CJ, Chu CJ, Massey SL, Abend NS, Thomas C, Rogers EE, McCulloch CE, Glass HC. Parent Mental Health and Family Coping over Two Years after the Birth of a Child with Acute Neonatal Seizures. Children (Basel). 2021 Dec 22;9(1):2. doi: 10.3390/children9010002. PMID: 35053627; PMCID: PMC8774381. [link] [pdf]

2020

Lemmon ME, Bonifacio SL, Shellhaas RA, Wusthoff CJ, Greenberg RG, Soul JS, Chang T, Chu CJ, Bates S, Massey SL, Abend NS, Cilio MR, Glass HC; Neonatal Seizure Registry. Characterization of Death in Infants With Neonatal Seizures. Pediatr Neurol. 2020 Dec;113:21-25. PMID: 32980743; PMCID: PMC7669564. [link] [pdf]

Glass HC, Grinspan ZM, Li Y, McNamara NA, Chang T, Chu CJ, Massey SL, Abend NS, Lemmon ME, Thomas C, McCulloch CE, Shellhaas RA; Neonatal Seizure Registry Study Group. Risk for infantile spasms after acute symptomatic neonatal seizures. Epilepsia. 2020 Dec;61(12):2774-2784. PMID: 33188528; PMCID: PMC7772063. [link] [pdf]

Thorn EL, Ostrowski LM, Chinappen DM, Jing J, Westover MB, Stufflebeam SM, Kramer MA, Chu CJ. Persistent abnormalities in Rolandic thalamocortical white matter circuits in childhood epilepsy with centrotemporal spikes. Epilepsia. 2020 Nov;61(11):2500-2508. PMID: 32944938; PMCID: PMC7722074. [link] [pdf]

Lemmon M, Glass H, Shellhaas RA, Barks MC, Bailey B, Grant K, Grossbauer L, Pawlowski K, Wusthoff CJ, Chang T, Soul J, Chu CJ, Thomas C, Massey SL, Abend NS, Rogers EE, Franck LS; Neonatal Seizure Registry. Parent experience of caring for neonates with seizures. Arch Dis Child Fetal Neonatal Ed. 2020 Nov;105(6):634-639. PMID: 32503792; PMCID: PMC7581607. [link] [pdf]

Martinet LE, Kramer MA, Viles W, Perkins LN, Spencer E, Chu CJ, Cash SS, Kolaczyk ED. Robust dynamic community detection with applications to human brain functional networks. Nat Commun. 2020 Jun 5;11(1):2785. PMID: 32503997; PMCID: PMC7275079. [link] [pdf]

Rubin DB, Angelini B, Shoukat M, Chu CJ, Zafar SF, Westover MB, Cash SS, Rosenthal ES. Electrographic predictors of successful weaning from anaesthetics in refractory status epilepticus. Brain. 2020 Apr 1;143(4):1143-1157. PMID: 32268366; PMCID: PMC7174057. [link] [pdf]

Franck LS, Shellhaas RA, Lemmon M, Sturza J, Soul JS, Chang T, Wusthoff CJ, Chu CJ, Massey SL, Abend NS, Thomas C, Rogers EE, McCulloch CE, Grant K, Grossbauer L, Pawlowski K, Glass HC; Neonatal Seizure Registry study group. Associations between Infant and Parent Characteristics and Measures of Family Well-Being in Neonates with Seizures: A Cohort Study. J Pediatr. 2020 Jun;221:64-71.e4. PMID: 32446494; PMCID: PMC7336525. [link] [pdf]

Ross EE, Stoyell SM, Kramer MA, Berg AT, Chu CJ. The natural history of seizures and neuropsychiatric symptoms in childhood epilepsy with centrotemporal spikes (CECTS). Epilepsy Behav. 2020 Feb;103(Pt A):106437. PMID: 31645314; PMCID: PMC8087164. [link] [pdf]

Peters JM, Hyde DE, Chu CJ, Boom M, Scherrer B, Madsen JR, Stone SS, Ouaalam H, Prabhu SP, Sahin M, Warfield SK. Lesion-Constrained Electrical Source Imaging: A Novel Approach in Epilepsy Surgery for Tuberous Sclerosis Complex. J Clin Neurophysiol. 2020 Jan;37(1):79-86. PMID: 31261349; PMCID: PMC6934937. [link] [pdf]

2019

Worden LT, Chinappen DM, Stoyell SM, Gold J, Paixao L, Krishnamoorthy K, Kramer MA, Westover MB, Chu CJ. The probability of seizures during continuous EEG monitoring in high-risk neonates. Epilepsia. 2019 Dec;60(12):2508-2518. PMID: 31745988; PMCID: PMC7083278. [link] [pdf]

Ostrowski LM, Song DY, Thorn EL, Ross EE, Stoyell SM, Chinappen DM, Eden UT, Kramer MA, Emerton BC, Morgan AK, Stufflebeam SM, Chu CJ. Dysmature superficial white matter microstructure in developmental focal epilepsy. Brain Commun. 2019;1(1):fcz002. PMID: 31608323; PMCID: PMC6777514. [link] [pdf]

Jing J, Sun H, Kim JA, Herlopian A, Karakis I, Ng M, Halford JJ, Maus D, Chan F, Dolatshahi M, Muniz C, Chu C, Sacca V, Pathmanathan J, Ge W, Dauwels J, Lam A, Cole AJ, Cash SS, Westover MB. Development of Expert-Level Automated Detection of Epileptiform Discharges During Electroencephalogram Interpretation. JAMA Neurol. 2020 Jan 1;77(1):103-108. PMID: 31633740; PMCID: PMC6806668. [link] [pdf]

Jing J, Herlopian A, Karakis I, Ng M, Halford JJ, Lam A, Maus D, Chan F, Dolatshahi M, Muniz CF, Chu C, Sacca V, Pathmanathan J, Ge W, Sun H, Dauwels J, Cole AJ, Hoch DB, Cash SS, Westover MB. Interrater Reliability of Experts in Identifying Interictal Epileptiform Discharges in Electroencephalograms. JAMA Neurol. 2020 Jan 1;77(1):49-57. PMID: 31633742; PMCID: PMC6806666. [link] [pdf]

Jing J, Herlopian A, Karakis I, Ng M, Halford JJ, Lam A, Maus D, Chan F, Dolatshahi M, Muniz CF, Chu C, Sacca V, Pathmanathan J, Ge W, Sun H, Dauwels J, Cole AJ, Hoch DB, Cash SS, Westover MB. Interrater Reliability of Experts in Identifying Interictal Epileptiform Discharges in Electroencephalograms. JAMA Neurol. 2020 Jan 1;77(1):49-57. PMID: 31633742; PMCID: PMC6806666. [link] [pdf]

Berg AT, Wusthoff C, Shellhaas RA, Loddenkemper T, Grinspan ZM, Saneto RP, Knupp KG, Patel A, Sullivan JE, Kossoff EH, Chu CJ, Massey S, Valencia I, Keator C, Wirrell EC, Coryell J, Millichap JJ, Gaillard WD. Immediate outcomes in early life epilepsy: A contemporary account. Epilepsy Behav. 2019 Aug;97:44-50. PMID: 31181428; PMCID: PMC8107814. [link] [pdf]

Song DY, Stoyell SM, Ross EE, Ostrowski LM, Thorn EL, Stufflebeam SM, Morgan AK, Emerton BC, Kramer MA, Chu CJ. Beta oscillations in the sensorimotor cortex correlate with disease and remission in benign epilepsy with centrotemporal spikes. Brain Behav. 2019 Mar;9(3):e01237. PMID: 30790472; PMCID: PMC6422718. [link] [pdf]

Kramer MA, Ostrowski LM, Song DY, Thorn EL, Stoyell SM, Parnes M, Chinappen D, Xiao G, Eden UT, Staley KJ, Stufflebeam SM, Chu CJ. Scalp recorded spike ripples predict seizure risk in childhood epilepsy better than spikes. Brain. 2019 May 1;142(5):1296-1309. PMID: 30907404; PMCID: PMC6487332. [link] [pdf]

Glass HC, Soul JS, Chu CJ, Massey SL, Wusthoff CJ, Chang T, Cilio MR, Bonifacio SL, Abend NS, Thomas C, Lemmon M, McCulloch CE, Shellhaas RA; Neonatal Seizure Registry study group. Response to antiseizure medications in neonates with acute symptomatic seizures. Epilepsia. 2019 Mar;60(3):e20-e24. PMID: 30790268; PMCID: PMC6443409. [link] [pdf]

2018

den Bakker H, Sidorov MS, Fan Z, Lee DJ, Bird LM, Chu CJ, Philpot BD. Abnormal coherence and sleep composition in children with Angelman syndrome: a retrospective EEG study. Mol Autism. 2018 Apr 27;9:32. PMID: 29719672; PMCID: PMC5924514. [link] [pdf]

Xie W, Ross EE, Kramer MA, Eden UT, Chu CJ. Timing matters: Impact of anticonvulsant drug treatment and spikes on seizure risk in benign epilepsy with centrotemporal spikes. Epilepsia Open. 2018 Jul 22;3(3):409-417. PMID: 30187012; PMCID: PMC6119752. [link] [pdf]

Spencer E, Martinet LE, Eskandar EN, Chu CJ, Kolaczyk ED, Cash SS, Eden UT, Kramer MA. A procedure to increase the power of Granger-causal analysis through temporal smoothing. J Neurosci Methods. 2018 Oct 1;308:48-61. PMID: 30031776; PMCID: PMC6200653. [link] [pdf]

Coryell J, Gaillard WD, Shellhaas RA, Grinspan ZM, Wirrell EC, Knupp KG, Wusthoff CJ, Keator C, Sullivan JE, Loddenkemper T, Patel A, Chu CJ, Massey S, Novotny EJ Jr, Saneto RP, Berg AT. Neuroimaging of Early Life Epilepsy. Pediatrics. 2018 Sep;142(3):e20180672. PMID: 30089657; PMCID: PMC6510984. [link] [pdf]

Berg AT, Chakravorty S, Koh S, Grinspan ZM, Shellhaas RA, Saneto RP, Wirrell EC, Coryell J, Chu CJ, Mytinger JR, Gaillard WD, Valencia I, Knupp KG, Loddenkemper T, Sullivan JE, Poduri A, Millichap JJ, Keator C, Wusthoff C, Ryan N, Dobyns WB, Hegde M. Why West? Comparisons of clinical, genetic and molecular features of infants with and without spasms. PLoS One. 2018 Mar 8;13(3):e0193599. PMID: 29518120; PMCID: PMC5843222. [link] [pdf]

Grinspan ZM, Shellhaas RA, Coryell J, Sullivan JE, Wirrell EC, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ Jr, Millichap J, Berg AT. Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy. JAMA Pediatr. 2018 Apr 1;172(4):352-360. PMID: 29435578; PMCID: PMC5875334. [link] [pdf]

Chu CJ. Targeting high frequency oscillations in epilepsy. Clin Neurophysiol. 2018 Jun;129(6):1307-1308. PMID: 29606497; PMCID: PMC6495532. [link] [pdf]

2017

Demarest ST, Shellhaas RA, Gaillard WD, Keator C, Nickels KC, Hussain SA, Loddenkemper T, Patel AD, Saneto RP, Wirrell E, Sánchez Fernández I, Chu CJ, Grinspan Z, Wusthoff CJ, Joshi S, Mohamed IS, Stafstrom CE, Stack CV, Yozawitz E, Bluvstein JS, Singh RK, Knupp KG; Pediatric Epilepsy Research Consortium. The impact of hypsarrhythmia on infantile spasms treatment response: Observational cohort study from the National Infantile Spasms Consortium. Epilepsia. 2017 Dec;58(12):2098-2103. PMID: 29105055; PMCID: PMC5863227. [link] [pdf]

Sidorov MS, Deck GM, Dolatshahi M, Thibert RL, Bird LM, Chu CJ, Philpot BD. Delta rhythmicity is a reliable EEG biomarker in Angelman syndrome: a parallel mouse and human analysis. J Neurodev Disord. 2017 May 8;9:17. PMID: 28503211; PMCID: PMC5422949. [link] [pdf]

Edlow BL, Chatelle C, Spencer CA, Chu CJ, Bodien YG, O’Connor KL, Hirschberg RE, Hochberg LR, Giacino JT, Rosenthal ES, Wu O. Early detection of consciousness in patients with acute severe traumatic brain injury. Brain. 2017 Sep 1;140(9):2399-2414. PMID: 29050383; PMCID: PMC6059097. [link]

Berg AT, Coryell J, Saneto RP, Grinspan ZM, Alexander JJ, Kekis M, Sullivan JE, Wirrell EC, Shellhaas RA, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Dobyns WB, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ Jr, Koh S. Early-Life Epilepsies and the Emerging Role of Genetic Testing. JAMA Pediatr. 2017 Sep 1;171(9):863-871. PMID: 28759667; PMCID: PMC5710404. [link] [pdf]

Shellhaas RA, Berg AT, Grinspan ZM, Wusthoff CJ, Millichap JJ, Loddenkemper T, Coryell J, Saneto RP, Chu CJ, Joshi SM, Sullivan JE, Knupp KG, Kossoff EH, Keator C, Wirrell EC, Mytinger JR, Valencia I, Massey S, Gaillard WD. Initial Treatment for Nonsyndromic Early-Life Epilepsy: An Unexpected Consensus. Pediatr Neurol. 2017 Oct;75:73-79. PMID: 28807611; PMCID: PMC5863237. [link] [pdf]

Glass HC, Shellhaas RA, Tsuchida TN, Chang T, Wusthoff CJ, Chu CJ, Cilio MR, Bonifacio SL, Massey SL, Abend NS, Soul JS; Neonatal Seizure Registry study group. Seizures in Preterm Neonates: A Multicenter Observational Cohort Study. Pediatr Neurol. 2017 Jul;72:19-24. PMID: 28558955; PMCID: PMC5863228. [link]  [pdf]

Shellhaas RA, Wusthoff CJ, Tsuchida TN, Glass HC, Chu CJ, Massey SL, Soul JS, Wiwattanadittakun N, Abend NS, Cilio MR; Neonatal Seizure Registry. Profile of neonatal epilepsies: Characteristics of a prospective US cohort. Neurology. 2017 Aug 29;89(9):893-899. PMID: 28733343; PMCID: PMC5577964. [link] [pdf]

Shellhaas RA, Chang T, Wusthoff CJ, Soul JS, Massey SL, Chu CJ, Cilio MR, Bonifacio SL, Abend NS, Tsuchida TN, Glass HC; Neonatal Seizure Registry Study Group. Treatment Duration After Acute Symptomatic Seizures in Neonates: A Multicenter Cohort Study. J Pediatr. 2017 Feb;181:298-301.e1. PMID: 27829512; PMCID: PMC5322461. [link] [pdf]

Chu CJ, Chan A, Song D, Staley KJ, Stufflebeam SM, Kramer MA. A semi-automated method for rapid detection of ripple events on interictal voltage discharges in the scalp electroencephalogram. J Neurosci Methods. 2017 Feb 1;277:46-55. PMID: 27988323; PMCID: PMC5290731. [link] [pdf]

2016

Knupp KG, Leister E, Coryell J, Nickels KC, Ryan N, Juarez-Colunga E, Gaillard WD, Mytinger JR, Berg AT, Millichap J, Nordli DR Jr, Joshi S, Shellhaas RA, Loddenkemper T, Dlugos D, Wirrell E, Sullivan J, Hartman AL, Kossoff EH, Grinspan ZM, Hamikawa L; Pediatric Epilepsy Research Consortium. Response to second treatment after initial failed treatment in a multicenter prospective infantile spasms cohort. Epilepsia. 2016 Nov;57(11):1834-1842. PMID: 27615012; PMCID: PMC5863234. [link] [pdf]

Herlopian A, Rosenthal ES, Chu CJ, Cole AJ, Struck AF. Extreme delta brush evolving into status epilepticus in a patient with anti-NMDA encephalitis. Epilepsy Behav Case Rep. 2016 Sep 25;7:69-71. PMID: 28616386; PMCID: PMC5459970. [link] [pdf]

Knupp KG, Coryell J, Nickels KC, Ryan N, Leister E, Loddenkemper T, Grinspan Z, Hartman AL, Kossoff EH, Gaillard WD, Mytinger JR, Joshi S, Shellhaas RA, Sullivan J, Dlugos D, Hamikawa L, Berg AT, Millichap J, Nordli DR Jr, Wirrell E; Pediatric Epilepsy Research Consortium. Response to treatment in a prospective national infantile spasms cohort. Ann Neurol. 2016 Mar;79(3):475-84. PMID: 26704170; PMCID: PMC5902168. [link] [pdf]

Glass HC, Shellhaas RA, Wusthoff CJ, Chang T, Abend NS, Chu CJ, Cilio MR, Glidden DV, Bonifacio SL, Massey S, Tsuchida TN, Silverstein FS, Soul JS; Neonatal Seizure Registry Study Group. Contemporary Profile of Seizures in Neonates: A Prospective Cohort Study. J Pediatr. 2016 Jul;174:98-103.e1. PMID: 27106855; PMCID: PMC4925241. [link] [pdf]

Shafi MM, Whitfield-Gabrieli S, Chu CJ, Pascual-Leone A, Chang BS. A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy. J Vis Exp. 2016 Nov 13;(117):53727. PMID: 27911366; PMCID: PMC5226225. [link] [pdf]

Chu CJ. Quick and accurate quantification of the premature brain. Clin Neurophysiol. 2016 Aug;127(8):2908-2909. PMID: 27236608; PMCID: PMC5310300. [link] [pdf]

< 2015

Chu CJ. High density EEG-what do we have to lose? Clin Neurophysiol. 2015 Mar;126(3):433-4. PMID: 25113273; PMCID: PMC4289454. [link] [pdf]

Matlis S, Boric K, Chu CJ, Kramer MA. Robust disruptions in electroencephalogram cortical oscillations and large-scale functional networks in autism. BMC Neurol. 2015 Jun 27;15:97. PMID: 26111798; PMCID: PMC4482270. [link] [pdf]

Shore J, Chu CJ, Bianchi MT. Power laws and fragility in flow networks. Soc Networks. 2013 Jan;35(1):116-123. PMID: 26082568; PMCID: PMC4465807. [link] [pdf]

Matlis S, Boric K, Chu CJ, Kramer MA. Erratum: Robust disruptions in electroencephalogram cortical oscillations and large-scale functional networks in autism. BMC Neurol. 2015 Aug 19;15:142. doi: 10.1186/s12883-015-0391-4. Erratum for: BMC Neurol. 2015;15:97. PMID: 26286517; PMCID: PMC4544798. [link] [pdf]

Ng MC, Gaspard N, Cole AJ, Hoch DB, Cash SS, Bianchi M, O’Rourke DA, Rosenthal ES, Chu CJ, Westover MB. The standardization debate: A conflation trap in critical care electroencephalography. Seizure. 2015 Jan;24:52-8. PMID: 25457454; PMCID: PMC4465375. [link] [pdf]

Chu CJ, Tanaka N, Diaz J, Edlow BL, Wu O, Hämäläinen M, Stufflebeam S, Cash SS, Kramer MA. EEG functional connectivity is partially predicted by underlying white matter connectivity. Neuroimage. 2015 Mar;108:23-33. PMID: 25534110; PMCID: PMC4323839. [link] [pdf]

Shafi MM, Vernet M, Klooster D, Chu CJ, Boric K, Barnard ME, Romatoski K, Westover MB, Christodoulou JA, Gabrieli JD, Whitfield-Gabrieli S, Pascual-Leone A, Chang BS. Physiological consequences of abnormal connectivity in a developmental epilepsy. Ann Neurol. 2015 Mar;77(3):487-503. PMID: 25858773; PMCID: PMC4394240. [link] [pdf]

Yaffe RB, Borger P, Megevand P, Groppe DM, Kramer MA, Chu CJ, Santaniello S, Meisel C, Mehta AD, Sarma SV. Physiology of functional and effective networks in epilepsy. Clin Neurophysiol. 2015 Feb;126(2):227-36. PMID: 25283711. [link] [pdf]

Armstrong-Javors A, Chu CJ. Child neurology: Exaggerated dermal melanocytosis in a hypotonic infant: a harbinger of GM1 gangliosidosis. Neurology. 2014 Oct 21;83(17):e166-8. PMID: 25332452; PMCID: PMC4222851. [link] [pdf]

Westover MB, Shafi MM, Bianchi MT, Moura LM, O’Rourke D, Rosenthal ES, Chu CJ, Donovan S, Hoch DB, Kilbride RD, Cole AJ, Cash SS. The probability of seizures during EEG monitoring in critically ill adults. Clin Neurophysiol. 2015 Mar;126(3):463-71. PMID: 25082090; PMCID: PMC4289643. [link] [pdf]

Lepage KQ, Kramer MA, Chu CJ. A statistically robust EEG re-referencing procedure to mitigate reference effect. J Neurosci Methods. 2014 Sep 30;235:101-16. PMID: 24975291; PMCID: PMC4160811. [link] [pdf]

Chu CJ, Leahy J, Pathmanathan J, Kramer MA, Cash SS. The maturation of cortical sleep rhythms and networks over early development. Clin Neurophysiol. 2014 Jul;125(7):1360-70. PMID: 24418219; PMCID: PMC4035415. [link] [pdf]

Boland TA, McGuone D, Jindal J, Rocha M, Cumming M, Rupprecht CE, Barbosa TF, de Novaes Oliveira R, Chu CJ, Cole AJ, Kotait I, Kuzmina NA, Yager PA, Kuzmin IV, Hedley-Whyte ET, Brown CM, Rosenthal ES. Phylogenetic and epidemiologic evidence of multiyear incubation in human rabies. Ann Neurol. 2014 Jan;75(1):155-60. PMID: 24038455; PMCID: PMC4118733. [link] [pdf]

Chu CJ, Kramer MA, Pathmanathan J, Bianchi MT, Westover MB, Wizon L, Cash SS. Emergence of stable functional networks in long-term human electroencephalography. J Neurosci. 2012 Feb 22;32(8):2703-13. doi: 10.1523/JNEUROSCI.5669-11.2012. PMID: 22357854; PMCID: PMC3361717. [link] [pdf]

Kramer MA, Truccolo W, Eden UT, Lepage KQ, Hochberg LR, Eskandar EN, Madsen JR, Lee JW, Maheshwari A, Halgren E, Chu CJ, Cash SS. Human seizures self-terminate across spatial scales via a critical transition. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21116-21. PMID: 23213262; PMCID: PMC3529091. [link] [pdf]

van Eeghen AM, Chu-Shore CJ, Pulsifer MB, Camposano SE, Thiele EA. Cognitive and adaptive development of patients with tuberous sclerosis complex: a retrospective, longitudinal investigation. Epilepsy Behav. 2012 Jan;23(1):10-5. PMID: 22099526. [link] [pdf]

Numis AL, Yellen MB, Chu-Shore CJ, Pfeifer HH, Thiele EA. The relationship of ketosis and growth to the efficacy of the ketogenic diet in infantile spasms. Epilepsy Res. 2011 Sep;96(1-2):172-5. PMID: 21700429. [link] [pdf]

Xin W, Mullen TE, Kiely R, Min J, Feng X, Cao Y, O’Malley L, Shen Y, Chu-Shore C, Mole SE, Goebel HH, Sims K. CLN5 mutations are frequent in juvenile and late-onset non-Finnish patients with NCL. Neurology. 2010 Feb 16;74(7):565-71. PMID: 20157158. [link] [pdf]

Chu-Shore CJ, Major P, Camposano S, Muzykewicz D, Thiele EA. The natural history of epilepsy in tuberous sclerosis complex. Epilepsia. 2010 Jul;51(7):1236-41. PMID: 20041940; PMCID: PMC3065368. [link] [pdf]

Gallagher A, Chu-Shore CJ, Montenegro MA, Major P, Costello DJ, Lyczkowski DA, Muzykewicz D, Doherty C, Thiele EA. Associations between electroencephalographic and magnetic resonance imaging findings in tuberous sclerosis complex. Epilepsy Res. 2009 Dec;87(2-3):197-202. PMID: 19783123. [link] [pdf]

Chu-Shore CJ, Major P, Montenegro M, Thiele E. Cyst-like tubers are associated with TSC2 and epilepsy in tuberous sclerosis complex. Neurology. 2009 Mar 31;72(13):1165-9. doi: 10.1212/01.wnl.0000345365.92821.86. PMID: 19332694. [link] [pdf]

Chu CJ, Jones TA. Experience-dependent structural plasticity in cortex heterotopic to focal sensorimotor cortical damage. Exp Neurol. 2000 Dec;166(2):403-14. PMID: 11085905. [link] [pdf]

Jones TA, Chu CJ, Grande LA, Gregory AD. Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats. J Neurosci. 1999 Nov 15;19(22):10153-63. PMID: 10559423; PMCID: PMC6782959. [link] [pdf]

Book Chapters

Larson A, Chu CJ and Thiele EA. Tuberous Sclerosis. The Causes of Epilepsy. Cambridge University Press 2018.

Thorn EL, Matlis S, Chu CJ. Neuroimaging Methods. The SAGE Encyclopedia of Intellectual and Developmental Disorders. Sage Publishing 2018.

Chu CJ and Thiele EA. Tuberous Sclerosis. The Causes of Epilepsy. Cambridge University Press 2011.

Chu CJ, Caviness VS, Cash SS. Neural networks in the developing brain. Network Approaches to Diseases of the Brain, Bentham e-book 2011.

Plotkin S and Chu CJ. The Phakomatoses. The Molecular and Genetic Basis of Neurological and Psychiatric Disease, 4th edition 2007.