Publications

L.-E. Martinet, M. A. Kramer, W. Viles, L. N. Perkins, E. Spencer, C. J. Chu, S. S. Cash, E. D. Kolaczyk. Robust dynamic community detection with applications to human brain functional networks. Nature Communications. (2020) doi:10.1038/s41467-020-16285-7.

D.B. Rubin, B. Angelini, M. Shoukat, C.J. Chu, S.F. Zafar, M.B. Westover, S.S. Cash, E.S. Rosenthal. Electrographic predictors of successful weaning from anaesthetics in refractory status epilepticus. Brain. (2020) doi:10.1093/brain/awaa069.

M. Lemmon, H. Glass, R.A. Shellhaas, M. C. Barks, B. Bailey, K. Grant, L. Grossbauer, K. Pawlowski, C.J. Wusthoff, T. Chang, J. Soul, C.J. Chu, C. Thomas, S.L. Massey, N.S. Abend, E.E. Rogers, L.S. Franck. Parent experience of caring for neonates with seizures. Arch Dis Child Fetal Neonatal Ed Epub. (2020) doi:10.1136/archdischild-2019-318612.

L.S. Franck, R.A. Shellhaas, M. Lemmon, J. Sturza, J.S. Soul, T. Chang, C.J. Wusthoff, C.J. Chu, S.L. Massey, N.S. Abend, C. Thomas, E.E. Rogers, C.E. McCulloch, K. Grant, L. Grossbauer, K. Pawlowski, H.C. Glass, R. Guillet, M. Barnes, T. Tsuchida, A. Numis, M.R. Cilio, S.L. Bonifacio. Associations between Infant and Parent Characteristics and Measures of Family Well-Being in Neonates with Seizures: A Cohort Study. The Journal of Pediatrics. (2020) doi: 10.1016/j.jpeds.2020.02.024.

D.B. Rubin, B. Angelini, M. Shoukat, C.J. Chu, S.F. Zafar, M.B. Westover, S.S. Cash, E.S. Rosenthal. Electrographic predictors of successful weaning from anaesthetics in refractory status epilepticus. Brain. (2020) doi: 10.1093/brain/awaa069.

L.T. Worden, D.M. Chinappen, S.M. Stoyell, J.Gold, L. Paixao, K. Krishnamoorthy, M.A. Kramer, M.B. Westover, C.J. Chu. The probability of seizures during continuous EEG monitoring in high‐risk neonates. Epilepsia. (2019) doi: 10.1111/epi.16387.

J. Jing, A. Herlopian, I. Karakis, M. Ng, J.J. Halford, A. Lam, D. Maus, F. Chan, M. Dolatshahi, C. Muniz, C. Chu, V. Sacca, J. Pathmanathan, W. Ge, H. Sun, J. Dauwels, A.J. Cole, D.B. Hoch, S.S. Cash, M.B. Westover. Interrater Reliability of Experts in Identifying Interictal Epileptiform Discharges in Electroencephalograms. JAMA Neurol. (2019) doi: 10.1001/jamaneurol.2019.3531.

J. Jing, H. Sun, J.A. Kim, A. Herlopian, I. Karakis, M. Ng, J.J. Halford, D. Maus, F. Chan, M. Dolatshahi, C. Muniz, C. Chu, V. Sacca, J. Pathmanathan, W. Ge, J. Dauwels, A. Lam, A. J. Cole, S.S. Cash, M. B. Westover. Development of Expert-Level Automated Detection of Epileptiform Discharges During Electroencephalogram Interpretation. JAMA Neurol. (2019) doi: 10.1001/jamaneurol.2019.3485.

E. E. Ross, S.M. Stoyell, M.A. Kramer, A. Berg, C.J. Chu, The natural history of seizures and neuropsychiatric symptoms in childhood epilepsy with centrotemporal spikes. Epilepsy Behav. (2019) doi: 10.1016/j.yebeh.2019.07.038.

J.M. Peters, D. Hyde, C.J. Chu, M. Boom, B. Scherrer, J. Madsen, S. Stone, H. Ouaalam, S. Prabhu, M. Sahin, S. K. Warfield. Lesion-Constrained Electrical Source Imaging: A novel approach in epilepsy surgery for Tuberous Sclerosis Complex. J Clin Neurophysiol. (2019) doi: 10.1097/WNP.0000000000000615.

L.M. Ostrowski, D.Y. Song, E.L. Thorn, E.E. Ross, S.M. Stoyell, D. Chinappen, U.T. Eden, M.A. Kramer, B.C. Emerton, A.K. Morgan, S.M. Stufflebeam, C.J. Chu. Dysmature superficial white matter microstructure in developmental focal epilepsy., Brain Communications. 1 (2019). doi: 10.1093/braincomms/fcz002.

D.Y. Song, S.M. Stoyell, E.E. Ross, L.M. Ostrowski, E.L. Thorn, S.M. Stufflebeam, A.K. Morgan, B.C. Emerton, M.A. Kramer, C.J. Chu, Beta oscillations in the sensorimotor cortex correlate with disease and remission in benign epilepsy with centrotemporal spikes., Brain Behav. 9 (2019) e01237. doi:10.1002/brb3.1237.

M.A. Kramer, L.M. Ostrowski, D.Y. Song, E.L. Thorn, S.M. Stoyell, M. Parnes, D. Chinappen, G. Xiao, U.T. Eden, K.J. Staley, S.M. Stufflebeam, C.J. Chu, Scalp recorded spike ripples predict seizure risk in childhood epilepsy better than spikes., Brain. 142 (2019) 1296–1309. doi:10.1093/brain/awz059.

H.C. Glass, J.S. Soul, C.J. Chu, S.L. Massey, C.J. Wusthoff, T. Chang, M.R. Cilio, S.L. Bonifacio, N.S. Abend, C. Thomas, M. Lemmon, C.E. McCulloch, R.A. Shellhaas, Response to antiseizure medications in neonates with acute symptomatic seizures., Epilepsia. 60 (2019) e20–e24. doi:10.1111/epi.14671.

A.T. Berg, C. Wusthoff, R.A. Shellhaas, T. Loddenkemper, Z.M. Grinspan, R.P. Saneto, K.G. Knupp, A. Patel, J.E. Sullivan, E.H. Kossoff, C.J. Chu, S. Massey, I. Valencia, C. Keator, E.C. Wirrell, J. Coryell, J.J. Millichap, W.D. Gaillard, Immediate outcomes in early life epilepsy: A contemporary account., Epilepsy Behav. 97 (2019) 44–50. doi:10.1016/j.yebeh.2019.05.011.

W. Xie, E.E. Ross, M.A. Kramer, U.T. Eden, C.J. Chu, Timing matters: Impact of anticonvulsant drug treatment and spikes on seizure risk in benign epilepsy with centrotemporal spikes., Epilepsia Open. 3 (2018) 409–417. doi:10.1002/epi4.12248.

E. Spencer, L.-E. Martinet, E.N. Eskandar, C.J. Chu, E.D. Kolaczyk, S.S. Cash, U.T. Eden, M.A. Kramer, A procedure to increase the power of Granger-causal analysis through temporal smoothing., J Neurosci Methods. 308 (2018) 48–61. doi:10.1016/j.jneumeth.2018.07.010.

Z.M. Grinspan, R.A. Shellhaas, J. Coryell, J.E. Sullivan, E.C. Wirrell, J.R. Mytinger, W.D. Gaillard, E.H. Kossoff, I. Valencia, K.G. Knupp, C. Wusthoff, C. Keator, N. Ryan, T. Loddenkemper, C.J. Chu, E.J.J. Novotny, J. Millichap, A.T. Berg, Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy., JAMA Pediatr. 172 (2018) 352–360. doi:10.1001/jamapediatrics.2017.5211.

H. den Bakker, M.S. Sidorov, Z. Fan, D.J. Lee, L.M. Bird, C.J. Chu, B.D. Philpot, Abnormal coherence and sleep composition in children with Angelman syndrome: a retrospective EEG study., Mol Autism. 9 (2018) 32. doi:10.1186/s13229-018-0214-8.

J. Coryell, W.D. Gaillard, R.A. Shellhaas, Z.M. Grinspan, E.C. Wirrell, K.G. Knupp, C.J. Wusthoff, C. Keator, J.E. Sullivan, T. Loddenkemper, A. Patel, C.J. Chu, S. Massey, E.J.J. Novotny, R.P. Saneto, A.T. Berg, Neuroimaging of Early Life Epilepsy., Pediatrics. 142 (2018). doi:10.1542/peds.2018-0672.

C.J. Chu, Targeting high frequency oscillations in epilepsy., Clin Neurophysiol. 129 (2018) 1307–1308. doi:10.1016/j.clinph.2018.03.001.

A.T. Berg, S. Chakravorty, S. Koh, Z.M. Grinspan, R.A. Shellhaas, R.P. Saneto, E.C. Wirrell, J. Coryell, C.J. Chu, J.R. Mytinger, W.D. Gaillard, I. Valencia, K.G. Knupp, T. Loddenkemper, J.E. Sullivan, A. Poduri, J.J. Millichap, C. Keator, C. Wusthoff, N. Ryan, W.B. Dobyns, M. Hegde, Why West? Comparisons of clinical, genetic and molecular features of infants with and without spasms., PLoS One. 13 (2018) e0193599. doi:10.1371/journal.pone.0193599.

M.S. Sidorov, G.M. Deck, M. Dolatshahi, R.L. Thibert, L.M. Bird, C.J. Chu, B.D. Philpot, Delta rhythmicity is a reliable EEG biomarker in Angelman syndrome: a parallel mouse and human analysis., J Neurodev Disord. 9 (2017) 17. doi:10.1186/s11689-017-9195-8.

R.A. Shellhaas, C.J. Wusthoff, T.N. Tsuchida, H.C. Glass, C.J. Chu, S.L. Massey, J.S. Soul, N. Wiwattanadittakun, N.S. Abend, M.R. Cilio, Profile of neonatal epilepsies: Characteristics of a prospective US cohort., Neurology. 89 (2017) 893–899. doi:10.1212/WNL.0000000000004284.

R.A. Shellhaas, T. Chang, C.J. Wusthoff, J.S. Soul, S.L. Massey, C.J. Chu, M.R. Cilio, S.L. Bonifacio, N.S. Abend, T.N. Tsuchida, H.C. Glass, Treatment Duration After Acute Symptomatic Seizures in Neonates: A Multicenter Cohort Study., J Pediatr. 181 (2017) 298-301.e1. doi:10.1016/j.jpeds.2016.10.039.

R.A. Shellhaas, A.T. Berg, Z.M. Grinspan, C.J. Wusthoff, J.J. Millichap, T. Loddenkemper, J. Coryell, R.P. Saneto, C.J. Chu, S.M. Joshi, J.E. Sullivan, K.G. Knupp, E.H. Kossoff, C. Keator, E.C. Wirrell, J.R. Mytinger, I. Valencia, S. Massey, W.D. Gaillard, Initial Treatment for Nonsyndromic Early-Life Epilepsy: An Unexpected Consensus., Pediatr Neurol. 75 (2017) 73–79. doi:10.1016/j.pediatrneurol.2017.06.011.

A. Herlopian, E.S. Rosenthal, C.J. Chu, A.J. Cole, A.F. Struck, Extreme delta brush evolving into status epilepticus in a patient with anti-NMDA encephalitis., Epilepsy Behav Case Rep. 7 (2017) 69–71. doi:10.1016/j.ebcr.2016.09.002.

H.C. Glass, R.A. Shellhaas, T.N. Tsuchida, T. Chang, C.J. Wusthoff, C.J. Chu, M.R. Cilio, S.L. Bonifacio, S.L. Massey, N.S. Abend, J.S. Soul, Seizures in Preterm Neonates: A Multicenter Observational Cohort Study., Pediatr Neurol. 72 (2017) 19–24. doi:10.1016/j.pediatrneurol.2017.04.016.

B.L. Edlow, C. Chatelle, C.A. Spencer, C.J. Chu, Y.G. Bodien, K.L. O’Connor, R.E. Hirschberg, L.R. Hochberg, J.T. Giacino, E.S. Rosenthal, O. Wu, Early detection of consciousness in patients with acute severe traumatic brain injury., Brain. 140 (2017) 2399–2414. doi:10.1093/brain/awx176.

S.T. Demarest, R.A. Shellhaas, W.D. Gaillard, C. Keator, K.C. Nickels, S.A. Hussain, T. Loddenkemper, A.D. Patel, R.P. Saneto, E. Wirrell, I. Sanchez Fernandez, C.J. Chu, Z. Grinspan, C.J. Wusthoff, S. Joshi, I.S. Mohamed, C.E. Stafstrom, C.V. Stack, E. Yozawitz, J.S. Bluvstein, R.K. Singh, K.G. Knupp, The impact of hypsarrhythmia on infantile spasms treatment response: Observational cohort study from the National Infantile Spasms Consortium., Epilepsia. 58 (2017) 2098–2103. doi:10.1111/epi.13937.

C.J. Chu, A. Chan, D. Song, K.J. Staley, S.M. Stufflebeam, M.A. Kramer, A semi-automated method for rapid detection of ripple events on interictal voltage discharges in the scalp electroencephalogram., J Neurosci Methods. 277 (2017) 46–55. doi:10.1016/j.jneumeth.2016.12.009.

A.T. Berg, J. Coryell, R.P. Saneto, Z.M. Grinspan, J.J. Alexander, M. Kekis, J.E. Sullivan, E.C. Wirrell, R.A. Shellhaas, J.R. Mytinger, W.D. Gaillard, E.H. Kossoff, I. Valencia, K.G. Knupp, C. Wusthoff, C. Keator, W.B. Dobyns, N. Ryan, T. Loddenkemper, C.J. Chu, E.J.J. Novotny, S. Koh, Early-Life Epilepsies and the Emerging Role of Genetic Testing., JAMA Pediatr. 171 (2017) 863–871. doi:10.1001/jamapediatrics.2017.1743.

M.M. Shafi, S. Whitfield-Gabrieli, C.J. Chu, A. Pascual-Leone, B.S. Chang, A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy., J Vis Exp. (2016). doi: 10.3791/53727.

K.G. Knupp, E. Leister, J. Coryell, K.C. Nickels, N. Ryan, E. Juarez-Colunga, W.D. Gaillard, J.R. Mytinger, A.T. Berg, J. Millichap, D.R.J. Nordli, S. Joshi, R.A. Shellhaas, T. Loddenkemper, D. Dlugos, E. Wirrell, J. Sullivan, A.L. Hartman, E.H. Kossoff, Z.M. Grinspan, L. Hamikawa, Pediatric Epilepsy Research Consortium, Response to second treatment after initial failed treatment in a multicenter prospective infantile spasms cohort., Epilepsia. 57 (2016) 1834–1842. doi:10.1111/epi.13557.

K.G. Knupp, J. Coryell, K.C. Nickels, N. Ryan, E. Leister, T. Loddenkemper, Z. Grinspan, A.L. Hartman, E.H. Kossoff, W.D. Gaillard, J.R. Mytinger, S. Joshi, R.A. Shellhaas, J. Sullivan, D. Dlugos, L. Hamikawa, A.T. Berg, J. Millichap, D.R.J. Nordli, E. Wirrell, Pediatric Epilepsy Research Consortium, Response to treatment in a prospective national infantile spasms cohort., Ann Neurol. 79 (2016) 475–484. doi:10.1002/ana.24594.

H.C. Glass, R.A. Shellhaas, C.J. Wusthoff, T. Chang, N.S. Abend, C.J. Chu, M.R. Cilio, D.V. Glidden, S.L. Bonifacio, S. Massey, T.N. Tsuchida, F.S. Silverstein, J.S. Soul, Contemporary Profile of Seizures in Neonates: A Prospective Cohort Study., J Pediatr. 174 (2016) 98-103.e1. doi:10.1016/j.jpeds.2016.03.035.

C.J. Chu, Quick and accurate quantification of the premature brain., Clin Neurophysiol. 127 (2016) 2908–2909. doi:10.1016/j.clinph.2016.04.024.

R.B. Yaffe, P. Borger, P. Megevand, D.M. Groppe, M.A. Kramer, C.J. Chu, S. Santaniello, C. Meisel, A.D. Mehta, S.V. Sarma, Physiology of functional and effective networks in epilepsy., Clin Neurophysiol. 126 (2015) 227–236. doi:10.1016/j.clinph.2014.09.009.

M.B. Westover, M.M. Shafi, M.T. Bianchi, L.M.V.R. Moura, D. O’Rourke, E.S. Rosenthal, C.J. Chu, S. Donovan, D.B. Hoch, R.D. Kilbride, A.J. Cole, S.S. Cash, The probability of seizures during EEG monitoring in critically ill adults., Clin Neurophysiol. 126 (2015) 463–471. doi:10.1016/j.clinph.2014.05.037.

M.M. Shafi, M. Vernet, D. Klooster, C.J. Chu, K. Boric, M.E. Barnard, K. Romatoski, M.B. Westover, J.A. Christodoulou, J.D.E. Gabrieli, S. Whitfield-Gabrieli, A. Pascual-Leone, B.S. Chang, Physiological consequences of abnormal connectivity in a developmental epilepsy., Ann Neurol. 77 (2015) 487–503. doi:10.1002/ana.24343.

M.C. Ng, N. Gaspard, A.J. Cole, D.B. Hoch, S.S. Cash, M. Bianchi, D.A. O’Rourke, E.S. Rosenthal, C.J. Chu, M.B. Westover, The standardization debate: A conflation trap in critical care electroencephalography., Seizure. 24 (2015) 52–58. doi:10.1016/j.seizure.2014.09.017.

S. Matlis, K. Boric, C.J. Chu, M.A. Kramer, Robust disruptions in electroencephalogram cortical oscillations and large-scale functional networks in autism., BMC Neurol. 15 (2015) 97. doi:10.1186/s12883-015-0355-8.

C.J. Chu, High density EEG-what do we have to lose?, Clin Neurophysiol. 126 (2015) 433–434. doi:10.1016/j.clinph.2014.07.003.

C.J. Chu, N. Tanaka, J. Diaz, B.L. Edlow, O. Wu, M. Hamalainen, S. Stufflebeam, S.S. Cash, M.A. Kramer, EEG functional connectivity is partially predicted by underlying white matter connectivity., Neuroimage. 108 (2015) 23–33. doi:10.1016/j.neuroimage.2014.12.033.

K.Q. Lepage, M.A. Kramer, C.J. Chu, A statistically robust EEG re-referencing procedure to mitigate reference effect., J Neurosci Methods. 235 (2014) 101–116. doi:10.1016/j.jneumeth.2014.05.008.

C.J. Chu, J. Leahy, J. Pathmanathan, M.A. Kramer, S.S. Cash, The maturation of cortical sleep rhythms and networks over early development., Clin Neurophysiol. 125 (2014) 1360–1370. doi:10.1016/j.clinph.2013.11.028.

T.A. Boland, D. McGuone, J. Jindal, M. Rocha, M. Cumming, C.E. Rupprecht, T.F.S. Barbosa, R. de Novaes Oliveira, C.J. Chu, A.J. Cole, I. Kotait, N.A. Kuzmina, P.A. Yager, I.V. Kuzmin, E.T. Hedley-Whyte, C.M. Brown, E.S. Rosenthal, Phylogenetic and epidemiologic evidence of multiyear incubation in human rabies., Ann Neurol. 75 (2014) 155–160. doi:10.1002/ana.24016.

A. Armstrong-Javors, C.J. Chu, Child neurology: Exaggerated dermal melanocytosis in a hypotonic infant: a harbinger of GM1 gangliosidosis., Neurology. 83 (2014) e166-168. doi:10.1212/WNL.0000000000000912.

J. Shore, C.J. Chu, M.T. Bianchi, Power laws and fragility in flow networks., Soc Networks. 35 (2013) 116–123. doi:10.1016/j.socnet.2013.01.005.

J. Cormier, C.J. Chu, Safety and efficacy of levetiracetam for the treatment of partial onset seizures in children from one month of age., Neuropsychiatr Dis Treat. 9 (2013) 295–306. doi:10.2147/NDT.S30224.

A.M. van Eeghen, C.J. Chu-Shore, M.B. Pulsifer, S.E. Camposano, E.A. Thiele, Cognitive and adaptive development of patients with tuberous sclerosis complex: a retrospective, longitudinal investigation., Epilepsy Behav. 23 (2012) 10–15. doi:10.1016/j.yebeh.2011.10.005.

M.A. Kramer, W. Truccolo, U.T. Eden, K.Q. Lepage, L.R. Hochberg, E.N. Eskandar, J.R. Madsen, J.W. Lee, A. Maheshwari, E. Halgren, C.J. Chu, S.S. Cash, Human seizures self-terminate across spatial scales via a critical transition., Proc Natl Acad Sci U S A. 109 (2012) 21116–21121. doi:10.1073/pnas.1210047110.

C.J. Chu-Shore, V.S. Caviness, S.S. Cash, Neural networks in the developing human brain, 2012. doi:10.2174/9781608050178112010121.

C.J. Chu, M.A. Kramer, J. Pathmanathan, M.T. Bianchi, M.B. Westover, L. Wizon, S.S. Cash, Emergence of stable functional networks in long-term human electroencephalography., J Neurosci. 32 (2012) 2703–2713. doi:10.1523/JNEUROSCI.5669-11.2012.

A.L. Numis, M.B. Yellen, C.J. Chu-Shore, H.H. Pfeifer, E.A. Thiele, The relationship of ketosis and growth to the efficacy of the ketogenic diet in infantile spasms., Epilepsy Res. 96 (2011) 172–175. doi:10.1016/j.eplepsyres.2011.05.012.

J.T. Leahy, C.J. Chu-Shore, J.L. Fisher, Clobazam as an adjunctive therapy in treating seizures associated with Lennox-Gastaut syndrome., Neuropsychiatr Dis Treat. 7 (2011) 673–681. doi:10.2147/NDT.S20173.

C.J. Chu-Shore, E.A. Thiele, Tuberous sclerosis complex, in: The Causes of Epilepsy: Common and Uncommon Causes in Adults and Children, Cambridge University Press, 2011: pp. 177–182.

C.J. Chu-Shore, M.A. Kramer, M.T. Bianchi, V.S. Caviness, S.S. Cash, Network analysis: applications for the developing brain., J Child Neurol. 26 (2011) 488–500. doi:10.1177/0883073810385345.

C.J. Chu-Shore, E.A. Thiele, Tumor growth in patients with tuberous sclerosis complex on the ketogenic diet., Brain Dev. 32 (2010) 318–322. doi:10.1016/j.braindev.2009.04.009.

C.J. Chu-Shore, E.A. Thiele, New drugs for pediatric epilepsy., Semin Pediatr Neurol. 17 (2010) 214–223. doi:10.1016/j.spen.2010.10.003.

C.J. Chu-Shore, P. Major, S. Camposano, D. Muzykewicz, E.A. Thiele, The natural history of epilepsy in tuberous sclerosis complex., Epilepsia. 51 (2010) 1236–1241. doi:10.1111/j.1528-1167.2009.02474.x.

C.J. Chu-Shore, B. Tseng, First Seizure, Pediatric perspective, E Medicine, pediatric neurology. (2010).

A. Gallagher, C.J. Chu-Shore, M.A. Montenegro, P. Major, D.J. Costello, D.A. Lyczkowski, D. Muzykewicz, C. Doherty, E.A. Thiele, Associations between electroencephalographic and magnetic resonance imaging findings in tuberous sclerosis complex., Epilepsy Res. 87 (2009) 197–202. doi:10.1016/j.eplepsyres.2009.09.001.

C.J. Chu-Shore, P. Major, M. Montenegro, E. Thiele, Cyst-like tubers are associated with TSC2 and epilepsy in tuberous sclerosis complex., Neurology. 72 (2009) 1165–1169. doi:10.1212/01.wnl.0000345365.92821.86.

C.J. Chu-Shore, M.P. Frosch, P.E. Grant, E.A. Thiele, Progressive multifocal cystlike cortical tubers in tuberous sclerosis complex: Clinical and neuropathologic findings., Epilepsia. 50 (2009) 2648–2651. doi:10.1111/j.1528-1167.2009.02193.x.

C.J. Chu, T.A. Jones, Experience-dependent structural plasticity in cortex heterotopic to focal sensorimotor cortical damage., Exp Neurol. 166 (2000) 403–414. doi:10.1006/exnr.2000.7509.

T.A. Jones, C.J. Chu, L.A. Grande, A.D. Gregory, Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats., J Neurosci. 19 (1999) 10153–10163.