Publications

2021

Nascimento F, Cochran RL, Zhow DZ, Scott JA, Chu CJ. Increasing SPECTations—ictal SPECT as a helpful tool in epilepsy surgery evaluation. Neurology 2021 (in press).

Stoyell S*, Baxter BS*, McLaren J, Kwon H, Chinappen DM, Ostrowski L, Zhu L, Grieco JA, Kramer MA, Morgan AK, Emerton BC, Manoach DS, Chu CJ. Diazepam induced sleep spindle increase correlates with cognitive recovery in a child with epileptic encephalopathy: case report. BMC Neurol (in press).

Grinspan ZM, Knupp KG, Patel AD, Yozawitz EG, Wusthoff CJ, Wirrell E, Valencia I, Singhal NS, Nordlii DR, Mytinger JR, Mitchell W, Keator CG, Loddenkemper T, Hussain SA, Harini C, Gaillard WD, Fernandez IS, Coryell J, Chu CJ, Berg AT, Shellhaas RA. Comparative effectiveness of initial treatment for infantile spasms in a contemporary US cohort. Neurology 2021 (in press).

Nadalin JK, Eden UT, Han X, Richardson RM, Chu CJ*, Kramer MA*. Application of a convolutional neural network for fully-automated detection of spike ripples in the scalp electroencephalogram. J Neurosci Methods 2021 (in press) [pdf]

Shellhaas R, Wusthoff C, Numis A, Chu CJ, Massey S, Abend N, Soul J, Change T, Lemmon M, McNamara N, Guillet R, Franck L, Sturza J, Glass H. Early-life epilepsy after acute symptomatic neonatal seizures: a prospective multicenter study. Epilepsia (in press). [pdf]

Glass HC, Soul JS, Chang T, Wusthoff CJ, Chu CJ, Massey SL, Abend NS, Lemmon M, Thomas C, Numis AL, Guillet R, Sturza J, McNarama NA, Rogers EE, Franck LS, McCulloch CE, Shellhaas RA. Safety of early discontinuation of antiseizure medication after acute symptomatic neonatal seizures. JAMA Neurology 2021;78(7):817-825. Highlighted in the Editorial: Payne ET and Wirrell EC. (2021) ‘Discontinuing antiseizure medication in neonates with acute symptomatic seizures—primum non nocere (in press). [pdf]

Wusthoff CJ, Sundaram V, Abend NS, Massey SL, Lemmon ME, Thomas C, McCulloch CE, Chang T, Soul JS, Chu CJ, Rogers EE, Bonifacio SL, Cilio MR, Glass HC, Shellhaas RA. Seizure control in neonates undergoing screening versus confirmatory EEG monitory. Neurology 2021 (in press)

McLaren JR, Shi W, Misko AL, Emerton BC, Chu CJ. Hippocampal sharp wave ripples during invasive monitoring: a physiologic finding. Clin Neurophysiol 2021; 132(5)1077-1079. [pdf]

Manzano, GS, Husain H.D., Chu, CJ. Kimchi EY. Intractable epilepsy and transient deficits in a patient with a history of HSV encephalitis. Neurology 2021; 96(14):679-681. [pdf]

Qiang L, Westover MB*, Zhang R*, Chu CJ*. Computational evidence for a competitive thalamocortical model of spikes and spindle activity in Rolandic epilepsy. Front Comput Neurosci 2021: 15:680549. [pdf]

Ostrowski LM, Spencer ER, Bird LM, Thibert R, Komorowski RW, Kramer MA, Chu CJ. Delta power robustly predicts cognitive function in Angelman syndrome. Annals of Clinical and Translational Neurology, 2021;8(7): 1433-1445. [pdf]

Zhu X, Shappell H, Kramer MA, Chu CJ, Kolaczyk E. Inferring the type of phase transitions undergone in epileptic seizures using random graph hidden Markov models for percolation in noisy dynamic networks. arXiv: 2021. [pdf]

Crocker B, Ostrowski L, Williams ZM, Doughterty DD, Eskandar E, Widge AS, Chu CJ, Cash SS, Paulk AC. Local and distant responses to single pulse electrical stimulation reflect different forms of connectivity. Neuroimage 2021;237:118094. [pdf]

Kramer MA, Stoyell SM, Chinappen D, Ostrowski LM, Spencer ER, Morgan AK, Emerton BC, Jing J, Westover MB, Eden UT, Stickgold R, Manoach DS, Chu CJ. Focal sleep spindle deficits reveal focal thalamocortical dysfunction and predict cognitive deficits in sleep activated developmental epilepsy. J Neuroscience. 2021; 41(8): 1816-1829. [pdf]

2020

Lemmon ME, Bonifacio SL, Shellhaas RA, Wusthoff CJ, Greenberg RG, Souls JS, Chang T, Chu CJ, Bates S, Massey SL, Abend NS, Cilio MR, Glass HC. Characterization of death in infants with neonatal seizures. Pediatr Neurol 2020; 113:21-25. [pdf]

Glass HC, Grinspan ZM, Li Y, McNamara NA, Chang T, Chu CJ, Massey SL, Abend NS, Lemmon ME, Thomas C, McCulloch CE, Shellhaas RA. Risk for infantile spasms after acute symptomatic neonatal seizures. Epilepsia 2020; 61(12):2774-2784. [pdf]

Thorn EL, Ostrowski LM, Chinappen DM, Jing J, Westover MB, Stufflebeam SM, Kramer MA, Chu CJ. Persistent abnormalities in Rolandic thalamocortical white matter circuits in childhood epilepsy with centrotemporal spikes. Epilepsia 2020;61(11):2500-2508. [pdf]

Lemmon M, Glass H, Shellhaas RA, Barks MC, Bailey B, Grank K, Grossbauer L, Pawlowski K, Wusthoff CJ, Chant T, Soul J, Chu CJ, Thomas C, Massey SL, Abend NS, Rogers EE, Franck LS. Parent experience of caring for neonates with seizures. Arch Dis Child Fetal Neonatal Ed 2020;105:634-39. [pdf]

Martinet LE*, Kramer MA*, Viles W, Perkins N, Spencer E, Chu CJ, Cash SS, Kolaczyk ED. Robust dynamic community tracking with applications in human brain functional networks Nat Comm 2020; 131(8):1782-1797. [pdf]

Rubin DB, Angelini B, Shoukat M, Chu CJ, Zafar SF, Westover MB, Cash SS, Rosenthal ES. Electrographic predictors of successful weaning from anaesthetics in refractory status epilepticus. Brain. 2020;143(4):1143‐1157.[pdf]

Franck LS, Shellhaas RA, Lemmon M, Sturza J, Soul JS, Chang T, Wusthoff CJ, Chu CJ, Massey SL, Abend NS, Thomas C, Rogers EE, McCulloch CE, Grant K, Grossbauer L, Pawlowski K, Glass HC. Associations between Infant and Parent Characteristics and Measures of Family Well-Being in Neonates with Seizures: A Cohort Study. J Pediatr. 2020;221:64‐71.e4.  [pdf]

Ross EE*, Stoyell SM*, Kramer MA, Berg AT, Chu CJ. The natural history of seizures and neuropsychiatric symptoms in childhood epilepsy with centrotemporal spikes (CECTS). Epilepsy Behav. 2020;103(Pt A):106437.[pdf]

Peters JM, Hyde DE, Chu CJ, Boom M, Scherrer B, Madsen JR, Stone SS, Ouaalam H, Prabhu SP,Sahin M, Warfield SK. Lesion-Constrained Electrical Source Imaging: A Novel Approach in Epilepsy Surgery for Tuberous Sclerosis Complex. J Clin Neurophysiol. 2020;37(1):79‐86.

2019

Worden L, Chinappen DK, Gold J, De Carvalho Paixao LC, Kramer MA, Westover MB, Chu CJ. The probability of seizures during continuous EEG monitoring in high-risk neonates. Epilepsia 2019; 60(12): 2508-2518. [pdf] Highlighted in the Editorial: Kotagal, P. (2020) ‘Continuous EEG Monitoring in Neonates: One Size Does Not Fit All’, Epilepsy Currents. https://doi.org/10.1177/1535759720923292.     

Jing J, Sun H, Kim JA, Herlopian A, Karakis I, Ng M, Halford JJ, Maus D, Chan F, Dolatshahi M, 25 Muniz C, Chu C, Sacca V, Pathmanathan J, Ge W, Dauwels J, Lam A, Cole AJ, Cash SS, Westover MB. Development of Expert-Level Automated Detection of Epileptiform Discharges During Electroencephalogram Interpretation. JAMA Neurol. 2019;77(1):103‐108. [pdf]

Jing J, Herlopian A, Karakis I, Ng M, Halford JJ, Lam A, Maus D, Chan F, Dolatshahi M, Muniz C, Chu C, Sacca V, Pathmanathan J, Ge W, Sun H, Dauwels J, Cole AJ, Hoch DB, Cash SS, Westover MB. Interrater Reliability of Experts in Identifying Interictal Epileptiform Discharges in Electroencephalograms JAMA Neurol. 2019;77(1):49‐57.[pdf]

Ostrowski LM, Song DY, Thorn EL, Ross EE, Stoyell SM, Chinappen DM, Eden UT, Kramer MA, Emerton BC, Morgan AK, Stufflebeam SM, Chu CJ. Dysmature superficial white matter microstructure in developmental focal epilepsy. Brain Commun. 2019;1(1):fcz002. doi:10.1093/braincomms/fcz002. [pdf]

Berg AT, Wusthoff C, Shellhaas RA, Loddenkemper T, Grinspan ZM, Saneto RP, Knupp KG, Patel A, Sullivan JE, Kossoff EH, Chu CJ, Massey S, Valencia I, Keator C, Wirrell EC, Coryell J, Millichap JJ, Gaillard WD. Immediate outcomes in early life epilepsy: A contemporary account. Epilepsy Behav 2019; 97:44-50.

Song D, Ross EE, Xie W, Ostrowski LM, Thorn EL, Sheehan S, Stufflebeam SM, Kramer MA, Chu CJ. Beta rhythm power in the perirolandic region correlates with time from seizure. Brain and Behavior 2019;9(3):e01237.

Kramer MA, Ostrowski LM, Stoyell SM, Song DY, Thorn EL, Stoyell SM, Parnes M, Chinappen DM, Xiao G, Staley KJ, Stufflebeam SM, Chu CJ. Scalp recorded spike ripples predict seizure risk in childhood epilepsy better than spikes. Brain 2019; 142(5):1296-1309. [pdf]

Berg AT, Wusthoff C, Shellhaas RA, Loddenkemper T, Grinspan ZM, Saneto RP, Knupp KG, Patel A, Sullivan JE, Kossoff EH, Chu CJ, Massey S, Valencia I, Keator C, Wirrell EC, Coryell J, Millichap JJ, Gaillard WD. Immediate outcomes in early life epilepsy: A contemporary account. Epilepsy Behav 2019;97:44-50.

Glass HC, Soul JS, Chu CJ, Massey SL, Wusthoff CJ, Chang T, Cilio MR, Bonifacio SL, Abend NS, Thomas C, Lemmon M, McCulloch CE, Shellhaas RA; Neonatal Seizure Registry study group. Response to antiseizure medications in neonates with acute symptomatic seizures. Epilepsia 2019 Mar;60(3):e20-e24.[pdf]

2018

den Bakker H, Sidorov MS, Fan Z, Lee DJ, Bird LM, Chu CJ, Philpot BD. Abnormal coherence and sleep composition in children with Angelman syndrome: a retrospective EEG study. Mol Autism 2018;9:32.[pdf]

Xie W, Ross EE, Chu CJ. Timing matters: impact of anticonvulsant drug treatment and spikes on seizure risk in benign epilepsy with centrotemporal spikes. Epilepsia Open. 2018;3:409-417.[pdf]

Spencer E, Martinet LE, Eskandar EN, Chu CJ, Kolaczyk ED, Cash SS, Eden UT, Kramer MA. A procedure to increase the power of Granger-causal analysis through temporal smoothing. J Neurosci Methods 2018; 308:48-61.[pdf]

Coryell J, Gaillard WD, Shellhaas RA, Grinspan ZM, Wirrell EC, Knupp KG, Wusthoff CJ, Keator C, Sullivan JE, Loddenkemper T, Patel A, Chu CJ, Massey S, Novotny EJ Jr, Saneto RP, Berg AT. Neuroimaging of Early Life Epilepsy. Pediatrics 2018 Sep;142(3).[pdf]

Berg AT, Chakravorty S, Joh S, Grinspan ZM, Shellhaas RA, Saneto RP, Poduri A, Wirrell EC, Coryell J, Chu CJ, Mytinger JR, Gaillard WD, Valencia I, Knupp KG, Loddenkemper T, Sullivan JE, Millichap JJ, Keator C, Wusthoff C, Ryan N, Dobyns WB, Hegde M. Why West? A comparative analysis of the clinical, genetic, and biological features in infants with and without infantile spasms. PlosOne 2018;13(3):e0193599. [pdf]

Grinspan ZM, Shellhaas RA, Coryell J, Sullivan JE, Wirrell EC, Mytinger JR, Gaillard WD, Kossoff 24 EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ Jr, Millichap J, Berg AT. Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy. JAMA Pediatr 2018; 172: 352-360.[pdf]

Larson A, Chu CJ and Thiele EA. Tuberous Sclerosis. The Causes of Epilepsy. Cambridge University Press 2018.

Thorn EL, Matlis S, Chu CJ. Neuroimaging Methods. The SAGE Encyclopedia of Intellectual and Developmental Disorders. Sage Publishing 2018.

2017

Demarest ST, Shellhaas RA, Gaillard WD, Keator C, Nickels KC, Hussain SA, Loddenkemper T, Patel AD, Saneto RP, Wirrell E, Sánchez Fernández I, Chu CJ, Grinspan Z, Wusthoff CJ, Joshi S, Mohamed IS, Stafstrom CE, Stack CV, Yozawitz E, Bluvstein JS, Singh RK, Knupp KG; Pediatric Epilepsy Research Consortium. The impact of hypsarrhythmia on infantile spasms treatment response: Observational cohort study from the National Infantile Spasms Consortium. Epilepsia 2017;58(12):2098-2103.[pdf]

Sidorov MS, Deck GM, Dolatshahi M, Thibert RL, Bird LM, Chu CJ*, Philpot BD* (co-last authors). Delta rhythmicity is a reliable EEG biomarker in Angelman syndrome. J Neurodev Disord. 2017; 9:17.[pdf]

Edlow BL, Chatelle C, Spencer-Salmon CC, Bodien YG, Hirschberg RE, Hochberg L, Chu CJ, Giacino JT, ES Rosenthal ES. Detecting consciousness in ICU patients with severe traumatic brain injury. Brain 2017; 140;9: 2399-2414.

Berg AT, Coryell J, Saneto RP, Grinspan ZM, Alexander JJ, Kekis M, Sullivan JE, Wirrell EC, Shellhaas RA, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Dobyns WB, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ Jr, Koh S. Early-Life Epilepsies and the Emerging Role of Genetic Testing. JAMA Pediatr 2017;171(9):863-871.[pdf]

Shellhaas RA, Berg AT, Grinspan ZM, Wusthoff CJ, Millichap JJ, Loddenkemper T, Coryell J, Saneto RP, Chu CJ, Joshi SM, Sullivan JE, Knupp KG, Kossoff EH, Keator C, Wirrell EC, Mytinger JR, Valencia I, Massey S, Gaillard WD. Initial Treatment for Nonsyndromic Early-Life Epilepsy: An Unexpected Consensus. Pediatr Neurol 2017;75:73-79.[pdf]

Glass HC, Shellhaas RA, Tsuchida TN, Chang T, Wusthoff CJ, Chu CJ, Cilio MR, Bonifacio SL, Massey SL, Abend NS, Soul JS; Neonatal Seizure Registry study group. Seizures in Preterm Neonates: A Multicenter Observational Cohort Study. Pediatr Neurol 2017;72:19-24.[pdf]

Shellhaas RA, Wusthoff CC, Tsuchida T, Glass HC, Chu CJ, Massey S, Soul JS, Wiwattanadittakun N, Abend N, Cilio MR. Profile of neonatal epilepsies: characteristics of a prospective US cohort. Neurology 2017;89: 893-899.[pdf]

Shellhaas RA, Chang T, Wusthoff CJ, Soul JS, Massey SL, Chu CJ, Cilio MR, Bonifacio SL, Abend NS, Tsuchida TN, Glass HC; Neonatal Seizure Registry Study Group. Treatment Duration After Acute Symptomatic Seizures in Neonates: A Multicenter Cohort Study. J Pediatr 2017;181:298-301.[pdf]

Chu CJ, Chan A, Song D, Staley KJ, Stufflebeam SM, Kramer MA. A semi-automated method for rapid detection of ripple events on interictal voltage discharges in the scalp electroencephalogram. J Neurosci Methods 2017; 277:46-55.[pdf]

Shellhaas RA, Wusthoff CJ, Tsuchida T, Glass JC, Chu CJ, Massey S, Soul JS, Wiwattanadittakun N, Abend N, Cilio MR. Management variability for treatment of seizures in neonates: a multi-center cohort study. J Pediatrics 2017; 181:298-301.

2016

Knupp KG, Leister E, Coryell J, Nickels KC, Ryan N, Juarez-Colunga E, Gaillard WD, Mytinger JR, Berg AT, Millichap J, Nordi DR, Joshi S, Shellhaas RA, Loddenkemper T, Dlugos D, Wirrell E, Sullivan J, Hartman AL, Kossoff EH, Grinspan ZM, Hamikawa L, and the Pediatric Epilepsy Research Consortium. Response to second treatment after initial failed treatment in a multicenter prospective infantile spasms cohort. Epilepsia 2016 Nov;57(11):1834-1842.[pdf]

Herlopian A, Rosenthal E, Chu CJ, Cole AJ, Struck AF. Extreme delta brushes evolving into status epilepticus in patients with anti-NMDA encephalitis. Epilepsy and Beh Case Report 2016;7:69-71.

Knupp KG, et al and the Pediatric Epilepsy Research Consortium. Response to treatment in a prospective national infantile spasms cohort. Annals of Neurology 2016; 79: 475-84.

Glass HC, Shellhaas RA, Wusthoff CJ, Chang T, Abend NS, Chu CJ, Cilio RC, Glidden DV, Bonafacio SL, Massey S, Tsuchida TN, Silvertein FS, Soul JS. Contemporary profile of seizures in neonates: A prospective cohort study of the Neonatal Seizure Registry J Pediatrics 2016;174:98-103.[pdf]

Shafi M, Chu CJ, Whitfield-Gabrieli S, Pascuel-Leone A, Chang B.A multimodal imaging- and stimulation-based method of evaluating connectivity-related brain excitability in patients with epilepsy. JoVE, 2016;117.[pdf]

< 2015

Matlis S, Kramer K, Chu CJ. Disruptions in cortical oscillations and large-scale functional networks in 23 autism BMC Neurology 2015;15(1):97-105.[pdf]

Ng MC, Gaspard N, Cole AJ, Hoch DB, Cash SS, Bianchi M, O’Rourke DA, Rosenthal ES, Chu CJ, Westover MB. The standardization debate: a conflation trap in critical care electroencephalography. Seizure 2015;24:52-58.[pdf]

Chu CJ, Tanaka N, Diaz J, Edlow B, Wu O, Hamalainen M, Stufflebeam S, Cash SS, Kramer MA. EEG functional connectivity is partially predicted by underlying white matter connectivity. Neuroimage 2015; 108:23-33.[pdf]

Shafi M, Vernet M, Klooster D, Barnard M, Romatoski K, Westover MB, Chu CJ, Boric K. Christodoulou J, Gabrieli J, Whitfield-Gabrieli S, Pascuel-Leone A, Chang B. Physiological consequences of abnormal connectivity in a developmental epilepsy. Annals of Neurology 2015;7793:487-503.

Yaffe RB, Borger P, Megevand P, Groppe DM, Kramer MA, Chu CJ, Santaniello S, Meisel C, Mehta A, Sarma SV. Physiology of functional and effective networks in epilepsy. Clin Neurophysiol. 2015;126(2):227‐236.

Armstrong-Javors A, Chu CJ. Child neurology: Exaggerated dermal melanocytosis in a hypotonic infant: a harbinger of GM1 gangliosidosis. Neurology. 2014;83(17):e166‐e168.

Westover MB, Shafi MM, Bianchi MT, Veras Rocha Moura LM, O’Rourke D, Rosenthal E, Chu CJ, Hoch DB, Kilbride R, Cole AJ, Cash SS. The probability of seizure detection among critically ill adults. Clin Neurophysiol 2014; 126:463-71. [pdf]

Lepage KQ, Kramer MA, Chu CJ. A statistically robust EEG re-referencing procedure to mitigate reference effect. J Neurosci Methods. 2014;235:101‐116.[pdf]

Chu CJ, Leahy JT, Pathmanathan J, Kramer MA, Cash SS. The maturation of cortical sleep rhythms and networks over early development. Clin Neurophys 2014; 125(7):1360-70.[pdf]

Boland T, McGuone D, Jindal J, Chu CJ, Cole AJ, Hedley-Whyte ET, Rosenthal ES. Phylogenetic and epidemiologic evidence of multi-year incubation in human rabies. Ann Neurol 2013; PMID: 24034855.

Shore JC, Chu CJ, Bianchi MT. Spontaneous power law degree distributions and turbulent dynamics in flow networks. Social Networks 2013;35:116-123.

Chu CJ, Kramer MA, Pathmanathan J, Bianchi MT, Westover MB, Wizon L, Cash SS. Emergence of stable functional networks in long-term human EEG. J Neurosci 2012. 32(8):2703-2713.[pdf]

Kramer MA, Truccolo W, Eden UT, Lepage KQ, Hochberg LR, Eskandar EN, Madsen JR, Lee JW, Maheshwari A, Halgren E, Chu CJ, Cash SS. Spontaneous seizure termination across spatial scales via a critical transition. Proc Natl Acad Sci USA 2012;109(51):21116-21.[pdf]

Van Eeghan AM, Chu CJ, Pulsifer MB, Camposano SE, Thiele EA. Cognitive and adaptive development of patients with tuberous sclerosis complex: A retrospective, longitudinal investigation. Epilepsy Beh 2012;23(1):10-5. [pdf]

Numis AL, Yellen MB, Chu CJ, Pfeifer HH, Thiele EA. The relationship of ketosis and growth to the efficacy of the ketogenic diet in infantile spasms. Epilepsy Res 2011;96(1-2):172-5.[pdf]

Chu CJ and Thiele EA. Tuberous Sclerosis. The Causes of Epilepsy. Cambridge University Press 2011.

Chu CJ, Caviness VS, Cash SS. Neural networks in the developing brain. Network Approaches to Diseases of the Brain, Bentham e-book 2011.

Xin W, Mullen TE, Kiely R, Min J, Feng X, Cao Y, O’Malley L, Shen Y, Chu CJ, Mole SE, Goebel HH, Sims K. CLN5 mutations are surprisingly frequent in both juvenile and late-onset non-Finnish NCL patients. Neurology 2010;74(7):565-71.[pdf]

Chu CJ, Major P, Camposano S, Muzykewicz, D, Thiele EA. The natural history of epilepsy in tuberous sclerosis complex. Epilepsia 2010;51(7):1236-41.[pdf]

Chu CJ*, Gallagher A*, Montenegro MA, Major P, Costello DJ, Lyczkowski BA, Muzykewicz D, Doherty C, Thiele EA. (*joint first-authors) Associations between electroencephalographic and magnetic resonance imaging findings in Tuberous Sclerosis Complex. Epilepsy Research.2009;87(2-3):197-202.[pdf]

Chu CJ, Major P, Montenegro M, Thiele E. Cyst-like cortical tubers are associated with TSC2, infantile spasms, and epilepsy in patients with Tuberous Sclerosis Complex. Neurology. 2009;72:1165-69.[pdf]

Plotkin S and Chu CJ. The Phakomatoses.The Molecular and Genetic Basis of Neurological and Psychiatric Disease, 4th edition 2007.

Chu CJ, Jones TA. Experience-dependent structural plasticity in cortex heterotopic to focal sensorimotor cortical damage. Experimental Neurology. 2000; 166: 403-414.[pdf]

Jones TA, Chu CJ, Grande LA, Gregory AD. Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats. J Neuroscience 1999; 19(22): 10153-63.[pdf]